Diclofenac and other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are Competitive Antagonists of the human P2X3 Receptor
L. Grohs, L. Cheng, S. Coenen, B. Haddad, A. Obrecht, I. Toklucu, L. Ernst, J. Koerner, G. Schmalzing, A. Lampert, J.-P. Machtens, R. Hausmann
This study identifies diclofenac and other NSAIDs as competitive antagonists of the human P2X3 receptor, with diclofenac showing strong inhibition of hP2X3R and hP2X2/3R.
bioRxiv · Dec 19, 2022 · PreprintPharmacology & Toxicology