D. Schols

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

This study shows that truncating the C-terminus of CXCL10 reduces its inflammatory activity but maintains its anti-angiogenic effects.

Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants

This paper demonstrates the use of cellular electrical impedance to monitor SARS-CoV-2 spike-mediated cell-cell fusion and assess fusion inhibitors and spike mutants.

Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern

This paper shows that UDA, a protein from stinging nettle, inhibits SARS-CoV-2 and its variants by blocking viral entry and fusion, with nanomolar potency.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

This paper develops a live biotherapeutic throat spray containing lactobacilli that inhibit respiratory viruses and induce interferon pathways in human cells and volunteers.

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model

The paper identifies potent anti-SARS-CoV-2 mAbs that cure infection in hamsters and demonstrates gene-based delivery for in vivo protection against variants.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening

The paper identifies a transient P-pocket in HIV-1 reverse transcriptase during DNA sliding and demonstrates fragment screening to target this pocket for inhibitor development.

Simultaneous inhibition of human CD4 and 4-1BB biogenesis suppresses cytotoxic T lymphocyte proliferation

This study shows that CADA inhibits CD4 and 4-1BB expression, suppressing CD8+ T cell proliferation and cytotoxic activity in vitro.

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.