Author

S. D. Larsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. R. Neubig· 3 shared E. M. Lisabeth· 2 shared S. A. Misek· 2 shared T. S. Dexheimer· 2 shared B. Auerbach· 1 shared B. R. Martin· 1 shared D. A. Fox· 1 shared D. Kahl· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

R. R. Neubig

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prevention of Drug-Induced Lung Fibrosis via Inhibition of the MRTF/SRF Transcription Pathway

K. Pawelec, M. Varnum, J. R. Harkema, B. Auerbach, S. D. Larsen, R. R. Neubig

This study shows that inhibiting the MRTF/SRF pathway with CCG-257081 prevents drug-induced lung fibrosis in mice, outperforming standard treatments in reducing fibrosis markers.

bioRxiv · Sep 9, 2021Pharmacology & Toxicology

AC2P20 selectively kills M. tuberculosis at acidic pH by depleting free thiols

S. J. Dechow, G. B. Coulson, M. W. Wilson, S. D. Larsen, R. B. Abramovitch

This study identifies AC2P20 as a compound that kills M. tuberculosis at acidic pH by depleting free thiols, supporting the role of redox homeostasis in Mtb survival.

bioRxiv · Mar 16, 2021Microbiology

Rho-mediated gene transcription promotes BRAF inhibitor resistance in de-differentiated melanoma cells

S. A. Misek, K. M. Appleton, T. S. Dexheimer, E. M. Lisabeth, R. Lo, S. D. Larsen, K. Gallo, R. R. Neubig

This study identifies RhoA-mediated gene transcription as a mechanism of BRAF inhibitor resistance in melanoma, showing that targeting this pathway can re-sensitize resistant cells to vemurafenib.

bioRxiv · Mar 31, 2019 · PreprintCancer Biology

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Anti-Fibrotic and Anti-Metastatic Compounds

E. M. Lisabeth, D. Kahl, I. Gopallawa, S. E. Haynes, S. A. Misek, P. L. Campbell, T. S. Dexheimer, D. Khanna, D. A. Fox, X. Jin, B. R. Martin, S. D. Larsen, R. R. Neubig

This study identifies pirin as the molecular target of the CCG-1423/CCG-203971 compounds, showing its role in modulating MRTF-dependent gene expression and fibrosis.

bioRxiv · Oct 31, 2018Pharmacology & Toxicology