Author

J. R. Harkema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Tovar· 1 shared B. Auerbach· 1 shared G. J. Smith· 1 shared J. M. Thomas· 1 shared K. Pawelec· 1 shared M. Varnum· 1 shared R. R. Neubig· 1 shared S. D. Larsen· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Tovar

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivSep 9, 2021

Prevention of Drug-Induced Lung Fibrosis via Inhibition of the MRTF/SRF Transcription Pathway

K. Pawelec, M. Varnum, J. R. Harkema…·R. R. Neubig

This study shows that inhibiting the MRTF/SRF pathway with CCG-257081 prevents drug-induced lung fibrosis in mice, outperforming standard treatments in reducing fibrosis markers.

DOI 10.1002/prp2.1028

mouseexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJun 5, 2019

Transcriptional profiling of the murine airway response to acute ozone exposure

A. Tovar, G. J. Smith, J. M. Thomas…·S. N. P. Kelada

This study profiles gene expression in murine airways after acute ozone exposure, identifying concentration-dependent changes in inflammation, injury, and gene expression in conducting airways and airway macrophages.

DOI 10.1093/toxsci/kfz219

mousebulk RNA-seq

𝕏 PostBluesky