The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria
R. K. Donegan, J. Copeland, S. Edgha, G. Brown, O. F. Hale, A. Mitra, H. Yang, H. A. Dailey, M. Niederweis, P. Jain, A. R. Reddi
This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.
bioRxiv · May 10, 2021 · PreprintMicrobiology