Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase
J. V. Dietz, M. M. Willoughby, R. B. Piel, T. A. Ross, I. Bohovych, H. G. Addis, J. L. Fox, W. N. Lanzilotta, H. A. Dailey, J. A. Wohlschlegel, A. R. Reddi, A. E. Medlock, O. Khalimonchuk
The paper investigates the role of MICOS in regulating ferrochelatase activity and heme biosynthesis in yeast, showing that MICOS disruption leads to toxic tetrapyrrole accumulation.
bioRxiv · Jun 1, 2021Biochemistry