A. R. Reddi

This study shows HO-2 binds and buffers oxidized labile heme in HEK293 cells, regulating heme homeostasis by controlling bioavailability rather than degrading heme under non-stress conditions.

The paper investigates the role of MICOS in regulating ferrochelatase activity and heme biosynthesis in yeast, showing that MICOS disruption leads to toxic tetrapyrrole accumulation.

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

This study uses genetically encoded heme sensors to show that C. albicans takes up heme from hemoglobin and hemin via different pathways and uses Hmx1 to prevent heme toxicity.

This study shows human ribosomes form G-quadruplexes in vivo that regulate heme bioavailability through interactions with G4 ligands and heme sensors.

The paper develops a live-cell assay to study heme trafficking and identifies ALAS and GTPases as regulators of heme mobilization from mitochondria to the nucleus.

The paper tests whether Fe2+ and Mn2+ could replace Mg2+ in ribosome function under ancient Earth conditions, finding they can mediate translation and associate with the ribosome.