Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.
S. A. A. Zaver, M. K. Sarkar, S. Egolf, J. Zou, A. Tiwaa, B. C. Capell, J. E. Gudjonsson, C. L. Simpson
This study uses human organotypic epidermis to show that SERCA2 deficiency disrupts keratinocyte adhesion via ERK signaling, and identifies MEK inhibition as a potential therapy for Darier disease.
bioRxiv · Mar 7, 2023Cell Biology