Author

C. L. Simpson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Tiwaa· 2 shared B. C. Paria· 2 shared C. J. Hansen· 2 shared J. E. Gudjonsson· 2 shared J. H. Rogers· 2 shared J. L. Herington· 2 shared S. L. Crockett· 2 shared S. Siricilla· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Tiwaa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ERK hyperactivation in epidermal keratinocytes impairs intercellular adhesion and drives Grover disease pathology

C. L. Simpson, A. Tiwaa, S. A. Zaver, C. J. Johnson, E. Y. Chu, P. W. Harms, J. E. Gudjonsson

This study shows ERK hyperactivation in keratinocytes causes impaired adhesion and drives Grover disease, supporting MEK inhibition as a potential therapy.

bioRxiv · Apr 30, 2024Cell Biology

Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy

S. Siricilla, C. J. Hansen, J. H. Rogers, D. De, C. L. Simpson, A. G. Waterson, G. A. Sulikowski, S. L. Crockett, N. Boatwright, J. J. Reese, B. C. Paria, J. M. Newton, J. L. Herington

This study evaluates the tocolytic efficacy of mundulone and its analog MA, showing synergism with atosiban and demonstrating their potential to delay preterm labor in mice.

bioRxiv · Jun 6, 2023Pharmacology & Toxicology

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.

S. A. A. Zaver, M. K. Sarkar, S. Egolf, J. Zou, A. Tiwaa, B. C. Capell, J. E. Gudjonsson, C. L. Simpson

This study uses human organotypic epidermis to show that SERCA2 deficiency disrupts keratinocyte adhesion via ERK signaling, and identifies MEK inhibition as a potential therapy for Darier disease.

bioRxiv · Mar 7, 2023Cell Biology

Identification of mundulone and mundulone acetate as natural products with tocolytic efficacy in mono- and combination-therapy with current tocolytics

S. Siricilla, C. J. Hansen, J. H. Rogers, C. L. Simpson, S. L. Crockett, J. Reese, B. C. Paria, J. L. Herington

This study identifies mundulone and mundulone acetate as natural products with tocolytic efficacy, showing differences in uterine-selectivity, synergistic potential, and cytotoxicity compared to existing tocolytics.

bioRxiv · May 13, 2021 · PreprintPharmacology & Toxicology