A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
A. Pons-Grifols, F. Tarres-Freixas, M. Perez, E. Riveira-Munoz, D. Raich-Regue, D. Perez-Zsolt, J. Munoz-Basagoiti, B. Tondelli, E. Pradenas, N. Izquierdo-Useros, S. Capdevila, J. Vergara-Alert, V. Urrea, J. Carrillo, E. Ballana, , J. Blanco
This paper introduces a knock-in mouse model for SARS-CoV-2 infection that replicates respiratory issues but avoids neurological disease seen in the K18-hACE2 model.
bioRxiv · Jun 11, 2024Microbiology