W. Shi

KIF5B drives meiotic chromosome dynamics via interaction with the KASH5-LINC complex

This study identifies KIF5B as a key component of the force-generating machinery for meiotic chromosome movements, interacting with the KASH5-LINC complex.

The single-cell make-up of adult diffuse glioma based on the 2021 WHO classification

This paper applies a fetal neural progenitor cell classification to adult diffuse gliomas, finding distinct THY1-CD24-EGFR+ and THY1-CD24-EGFR- cell populations across IDH mutant and IDHwt gliomas.

What scRNA sequencing taught us about MGMT expression in glioblastoma

The paper uses scRNA-seq data to analyze MGMT expression in glioblastoma and finds that MGMT expression is low in methylated samples and varies in unmethylated samples, with potential implications for survival.

Charge distribution and helical content tune the binding of septins amphipathic helix domain to lipid membranes

This study investigates how charge distribution and helical content of amphipathic helix domains affect septin binding to lipid membranes using simulations and experiments.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy

This study uses expansion microscopy to differentiate adhesive interactions between microbial cells in biofilms at the single-cell level.

CCSer2 gates dynein activity at the cell periphery

The paper identifies CCSer2 as a protein that gates dynein activity at the cell periphery by inhibiting its regulator Ndel1, enabling spatially restricted dynein activation.

Viral diversiy within marine biofilms and their potential roles in microbially influenced corrosion

This study analyzes viral communities in marine biofilms on 8 materials to explore their roles in microbially influenced corrosion, finding viruses influence corrosion through interactions with corrosive microbes.

Transcription network of SLC7A11 (xCT) in colon cancer provides clinical targets for metabolic regulation and cell proliferation

The paper analyzes RNA-seq data from CRC patients to identify SLC7A11's role in metabolic regulation and cell proliferation, linking it to clinical outcomes and therapeutic responses.

High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

This paper develops a high refractive index imaging buffer to improve 3D SMLM imaging depth in thick samples by reducing RI mismatch and enhancing image quality.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

Enhanced NK cell proficiency in solid tumors through antigen-specific memory via NKG2C/A-HLA-E/ABC recruited to tumors by CXCR2

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.

Mutating the arginine residue within the FRNK motif of HC-Pro yield highly attenuated strains that confer complete cross protection against telosma mosaic virus (TelMV) in passion fruit (Passiflora edulis)

The evolutionary and molecular history of a chikungunya virus outbreak lineage

This study traces the evolutionary origins and molecular changes of a chikungunya virus outbreak in Thailand, identifying mutations linked to increased virulence and transmission.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

Persistent enrichment of multidrug resistant Klebsiella in oral and nasal communities during long-term starvation

This study shows that Klebsiella outcompetes other microbes in oral and nasal communities during starvation, contributing to its persistence and potential pathogenicity.

VaxSeer: Selecting influenza vaccines through evolutionary and antigenicity models

VaxSeer selects influenza vaccine strains using evolutionary and antigenicity models to predict future effectiveness, outperforming annual recommendations.

Fast and universal single molecule localization using multi-dimensional point spread functions

This paper introduces a GPU-based B-spline PSF modeling method for fast and accurate high-dimensional single molecule analysis.

Highly localized chemical sampling at sub-second temporal resolution enabled with a silicon nanodialysis platform at exceedingly slow flows.

This paper introduces a silicon nanodialysis platform with sub-second temporal and 100μm spatial resolution, achieving 100-1000x better performance than traditional microdialysis.

Episymbiotic bacterium induces intracellular lipid droplet production in its host bacteria

This study investigates the interaction between Saccharibacteria TM7x and its host XH001, revealing TM7x-induced lipid droplet formation in XH001 and its protective role under stress.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

Exploiting effector - host interactions using TurboID-based proximity labeling

The paper identifies host proteins interacting with the Ustilago maydis effector UmSee1 using TurboID-based proximity labeling, revealing three ubiquitin-proteasome pathway proteins involved in tumor formation during infection.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.