Author

S. G. Sligar

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. G. Stephen· 1 shared M. A. McLean· 1 shared

Activity by Year

2019-2019 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperCancer Biology

A. G. Stephen

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1 paper

Recent·Most cited

Cancer BiologybioRxivMay 2, 2019

PIP2 Influences the Conformational Dynamics of Membrane bound KRAS4b

M. A. McLean, A. G. Stephen, S. G. Sligar

This study shows that PIP2 in the membrane bilayer promotes KRAS4b G-domain interactions, altering its conformational dynamics and potentially regulating its activity.

DOI 10.1021/acs.biochem.9b00395

experimental assaymechanistic / dynamical model

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