Cancer BiologybioRxiv
Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment
S. Izreig, A. Gariepy, A. O. Donayo…·R. G. Jones
The paper shows that miR-17~92 expression in Myc+ tumors increases sensitivity to biguanide treatment by disrupting bioenergetic stability in lymphoma cells.
DOI 10.1016/j.xcrm.2020.100014