Cell BiologybioRxivPreprint
Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
J. Garcia Morato, F. Hans, F. von Zweydorf…·P. J. Kahle
This study identifies K136 acetylation as a key modifier of TDP-43's RNA binding and phase separation, leading to pathological aggregation, and shows SIRT1's role in deacetylating and reducing this aggregation.
DOI 10.1101/2020.05.26.104356