S. J. Saupe

The paper identifies a third amyloid signaling pathway in Podospora anserina involving a PP-motif that forms prions and partially cross-seeds with human RHIM prions, suggesting evolutionary conservation of amyloid-based cell-death mechanisms.

The paper identifies bacterial amyloid signaling motifs related to fungal and mammalian motifs and shows they form prion-like structures in fungi and in vitro.