Signaling protein abundance modulates the strength of the Spindle Assembly Checkpoint
C. Chen, L. Humphrey, S. Jema, S. Karmarkar, F. Ferrari, A. Joglekar
This study shows that the abundance of SAC proteins like Bub1 affects their recruitment to kinetochores and SAC signaling activity, with lower abundance reducing signaling and higher abundance increasing it.
bioRxiv · May 10, 2022 · PreprintCell Biology