B. Roy

Fermented polyherbal formulation restored ricinoleic acid-induced diarrhea in Sprague Dawley rats and exhibited in vitro antibacterial effect on multiple antibiotics resistant gastric pathogens

This paper evaluates a polyherbal formulation AP-01 for treating ricinoleic acid-induced diarrhea in rats and demonstrates its in vitro antibacterial activity against antibiotic-resistant gastric pathogens.

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

The Structural Flexibility of MAD1 Facilitates the Assembly of the Mitotic Checkpoint Complex

This study shows that structural flexibility in MAD1's hinge region is crucial for efficient MCC assembly and SAC signaling, with implications for understanding mitotic checkpoint function.

N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

This study investigates how N1-methylpseudouridine and pseudouridine modifications affect mRNA decoding during translation, showing they influence amino acid misincorporation depending on codon position and tRNA context.

Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling

This study shows Aurora B kinase directly promotes MCC production by working downstream of Mps1 in budding yeast and human cells, enhancing SAC signaling.

Kre28-Spc105 interaction is essential for Spc105 loading at the kinetochore.

This study shows that the Kre28-Spc105 interaction is essential for Spc105 recruitment at the kinetochore, which is necessary for proper chromosome biorientation and segregation.

ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation

This paper shows ProLung-budesonide inhibits SARS-CoV-2 replication in vitro and reduces lung inflammation and airway hyperresponsiveness in mice.

Direct shoot regeneration from cotyledon, leaf and root of Citrus jambhiri Lush.

This study demonstrates direct shoot regeneration from cotyledons, leaves, and roots of Citrus jambhiri using tissue culture techniques, with varying success rates and plantlet health outcomes.

P-elements strengthen reproductive isolation within the Drosophila simulans species complex

The paper investigates whether P-elements strengthen reproductive isolation between Drosophila simulans and its sister species by analyzing hybrid fecundity in crosses with differing PE status.

Pure species discriminate against hybrids in the Drosophila melanogaster species subgroup

The paper investigates whether F1 hybrids between Drosophila species are less attractive than pure species and finds that pure species strongly discriminate against hybrids.

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

An agent-based model of the Foraging Ascomycete Hypothesis

The paper constructs an agent-based model to explore the ecological advantages of viaphytism in fungal dispersal strategies under different environmental conditions.

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness the Spindle Assembly Checkpoint

This study shows that the balance between SAC strength and responsiveness is determined by the number and binding affinity of MELT motifs in Spc105/KNL1.

Minimization of cross-talk between mitotic Checkpoint silencing and error correction

The paper shows that yeast kinetochores use separate PP1 sources and delay SAC silencing to prevent cross-talk between checkpoint silencing and error correction, ensuring accurate chromosome segregation.