Author

A. Joglekar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Roy· 3 shared C. Chen· 3 shared A. N. Fontan· 2 shared L. Humphrey· 2 shared S. J. Y. Han· 2 shared S. Jema· 2 shared A. A. Kukreja· 1 shared A. Alex· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

B. Roy

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Author profile →

6 papers

Recent·Most cited

The Structural Flexibility of MAD1 Facilitates the Assembly of the Mitotic Checkpoint Complex

C. Chen, V. Piano, A. Alex, S. Han, P. J. Huis in t Veld, B. Roy, A. Musacchio, A. Joglekar

This study shows that structural flexibility in MAD1's hinge region is crucial for efficient MCC assembly and SAC signaling, with implications for understanding mitotic checkpoint function.

bioRxiv · Jun 29, 2022 · PreprintCell Biology

Signaling protein abundance modulates the strength of the Spindle Assembly Checkpoint

C. Chen, L. Humphrey, S. Jema, S. Karmarkar, F. Ferrari, A. Joglekar

This study shows that the abundance of SAC proteins like Bub1 affects their recruitment to kinetochores and SAC signaling activity, with lower abundance reducing signaling and higher abundance increasing it.

bioRxiv · May 10, 2022 · PreprintCell Biology

Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling

B. Roy, S. J. Y. Han, A. N. Fontan, S. Jema, A. Joglekar

This study shows Aurora B kinase directly promotes MCC production by working downstream of Mps1 in budding yeast and human cells, enhancing SAC signaling.

Current Biology · Jan 1, 2022Peer-reviewedCell Biology

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signaling

A. Banerjee, C. Chen, L. Humphrey, J. J. Tyson, A. Joglekar

This study shows that Bub1-mediated BubR1 recruitment to kinetochores enhances SAC signaling and reveals BubR1's dual role in SAC activation and silencing.

bioRxiv · Aug 12, 2021Cell Biology

Microtubule attachment and centromeric tension shape the protein architecture of the human kinetochore

A. Joglekar, A. A. Kukreja, S. Kavuri

The paper uses Forster Resonance Energy Transfer to study kinetochore-microtubule attachments in human cells, finding that Ndc80 complex domains cluster at microtubule plus-ends in response to tension.

bioRxiv · Feb 11, 2020Cell Biology

The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness the Spindle Assembly Checkpoint

B. Roy, A. Joglekar, A. N. Fontan, S. J. Y. Han

This study shows that the balance between SAC strength and responsiveness is determined by the number and binding affinity of MELT motifs in Spc105/KNL1.

bioRxiv · Jan 7, 2020Cell Biology