Cancer BiologybioRxiv
Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition
E. Peer, S. K. Aichberger, F. Vilotic…·F. Aberger
This study identifies CSNK1D as a novel therapeutic target in Hedgehog-GLI driven cancers, showing its inhibition reduces tumor-initiating cell growth in both SMO-sensitive and -resistant settings.
DOI 10.3390/cancers13164227