Cell BiologyCellular and Molecular Life SciencesPeer-reviewed
Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
S. Yeruva, K. Stangner, A. Jungwirth…·J. Waschke
This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.
DOI 10.1007/s00018-023-04853-1