S. Kant

TNF-alpha promotes cilia elongation via Mixed Lineage Kinases signaling.

This study shows TNF-alpha elongates cilia in retinal epithelial cells via MLK signaling, while heat stress reduces ciliated cells independently of TNF-alpha.

Quinolinate promotes alternatively activated macrophage-induced immune tolerance in glioblastoma through the NMDA/PPARγ signaling axis

The paper identifies quinolinate as a metabolic checkpoint in glioblastoma that promotes immune tolerance via NMDA/PPARγ signaling and suggests kynureninase as a therapeutic target.

Rescue of transcriptional pausing in metabolic genes jumpstarts Salmonella antioxidant defenses

This study shows that Gre factors resolve transcriptional pauses in metabolic genes, enhancing Salmonella's antioxidant defenses against host phagocyte NADPH oxidase.

Automated Hyperspectral Vegetation Index Derivation Using A Hyperparameter Optimization Framework for High-Throughput Plant Phenotyping

This paper introduces AutoVI, an automated system for generating trait-specific hyperspectral vegetation indices, which outperforms existing indices in estimating chlorophyll and sugar content in wheat.

Mitogen Kinase Kinase (MKK7) controls cytokine production in vitro and in vivo in mice

This study shows MKK7 is essential for JNK activation and cytokine production in macrophages in vitro and in vivo, while MKK4 has a minor role in cytokine production during inflammation.

PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1

This study identifies a PGC-1-TERT-HMOX1 axis that regulates endothelial response to laminar fluid shear stress, promoting alignment and stability.

Automated Machine Learning for High-Throughput Image-Based Plant Phenotyping

This study compares AutoML and transfer learning for image-based plant phenotyping using wheat lodging assessment, finding AutoKeras generates faster models with comparable accuracy.