Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids
S. A. Rocco, L. Koneva, L. Y. M. Middleton, T. Thong, S. Solanki, S. Karram, K. Nambunmee, C. Harris, L. S. Rozek, M. A. Sartor, Y. M. Shah, J. Colacino
This study shows cadmium exposure inhibits branching morphogenesis and HIF-1α activity in human breast organoids, suggesting it disrupts mammary gland development rather than promoting cancer.
bioRxiv · Nov 3, 2017Pharmacology & Toxicology