S. Solanki

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

Structural enrichment attenuates colitis-associated colon cancer

The paper investigates how enriched versus impoverished housing conditions affect tumorigenesis in a mouse model of colitis-associated colon cancer, finding enriched housing reduces tumor burden.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

Mutations in a barley cytochrome P450 gene enhances pathogen induced programmed cell death and cutin layer instability

This paper identifies a barley cytochrome P450 gene, Nec3, that regulates serotonin biosynthesis, PCD, and cutin layer stability in response to pathogen infection.

Intestinal ferritinophagy is regulated by HIF-2 and is essential for systemic iron homeostasis

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

Localization of hyphal growth associated with mycotoxin production during the malting of Fusarium head blight infected grains

The paper localizes Fusarium hyphal growth in FHB-infected grains during malting and links it to mycotoxin production using microscopy and metagenomics.

rcs5-mediated spot blotch resistance in barley is conferred by wall-associated kinases that resist pathogen manipulation

This paper identifies Sbs1 and Sbs2 as recessive resistance genes in barley that resist manipulation by the hemi-biotrophic pathogen Bipolaris sorokiniana, conferring resistance to spot blotch.

Visualization of spatial gene expression in plants by modified RNAscope fluorescent in situ hybridization

The paper optimizes the RNAscope RNA-ISH method for plant tissues, enabling spatial gene expression visualization in barley and Arabidopsis.

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

This study examines the long-term metabolic effects of acute dioxin exposure in male and female mice, revealing sex-dependent differences in insulin levels and beta cell function.

Cadmium exposure inhibits branching morphogenesis and causes alterations consistent with HIF-1α inhibition in human primary breast organoids

This study shows cadmium exposure inhibits branching morphogenesis and HIF-1α activity in human breast organoids, suggesting it disrupts mammary gland development rather than promoting cancer.