Cell BiologybioRxiv
Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome
E. Radaelli, C.-A. Assenmacher, E. Banerjee…·M. Spinazzi
This study shows that PARL deficiency in mice causes testicular atrophy and male infertility due to ferroptosis in spermatocytes, independent of neurodegeneration.