Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification
S. Kolay, A. R. Vega, D. A. Dodd, V. A. Perez, O. M. Kashmer, C. L. White, M. I. Diamond
This study investigates how exogenous tau seeds are cleared or amplified within cells, finding they are mostly lysosomally degraded but a small fraction enters the cytosol to replicate and is cleared by the proteasome.
bioRxiv · Jan 3, 2022Cell Biology