R. PADINJAT

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.

This study shows that PIP4K regulates cell size and autophagy in Drosophila by controlling PI3P levels, with implications for neurodegeneration and tumour growth.

This study generates human stem cell lines from Lowe Syndrome patients to investigate the cellular and biochemical mechanisms of brain development defects caused by OCRL1 mutations.

This study identifies a septin 7 and Sip1 mediated mechanism that couples PIP5K activity to PLC mediated PI(4,5)P2 depletion during phototransduction in Drosophila.