Author

M. Zenke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 8 Research Focus:cell type annotation· 7 Research Focus:differential expression· 4 Research Focus:drug response / drug discovery· 4 Research Focus:cell signaling & trafficking· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

W. Wagner· 4 shared M. A. Szymanski de Toledo· 3 shared N. Chatain· 3 shared R. Goetzke· 3 shared S. Koschmieder· 3 shared T. H. Bruemmendorf· 3 shared A. Maurer· 2 shared A. Sechi· 2 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCell Biology

W. Wagner

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

YAP1 is essential for self-organized differentiation of pluripotent stem cells

K. Zeevaert, R. Goetzke, M. H. Elsafi Mabrouk, M. Schmidt, C. Maassen, A.-C. Henneke, C. He, A. Gillner, M. Zenke, W. Wagner

This study shows YAP1 is critical for germ layer specification in iPSCs, particularly in self-organized embryoid bodies, through NODAL pathway activation.

bioRxiv · Sep 29, 2022Cell Biology

A lncRNA identifies IRF8 enhancer element in negative feedback control of dendritic cell differentiation

H. Xu, Z. Li, C.-C. Kuo, K. Goetz, T. Look, M. A. Szymanski de Toledo, K. Sere, I. Gesteira Costa Filho, M. Zenke

The paper identifies a long non-coding RNA that regulates IRF8 autoactivation through a negative feedback loop in dendritic cell differentiation.

bioRxiv · Aug 11, 2022Cell Biology

The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates

M. H. Elsafi Mabrouk, R. Goetzke, G. Abagnale, B. Yesilyurt, L. Salz, K. Zeevaert, Z. Ma, M. A. S. Toledo, R. Li, I. G. Costa, V. Pachauri, U. Schnakenberg, M. Zenke, W. Wagner

The paper shows that self-organization in iPSC colonies continues in 3D aggregates formed after detachment from substrates, with maintained gene expression patterns.

Biomaterials · Mar 1, 2022Peer-reviewedCell Biology

DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation

O. Cypris, J. Franzen, J. Frobel, P. Glueck, C.-C. Kuo, S. Schmitz, S. Nuechtern, M. Zenke, W. Wagner

bioRxiv · Dec 15, 2021Cell Biology

CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes

K. Olschok, L. Han, M. A. S. de Toledo, J. Boehnke, M. Grasshoff, I. G. Costa, A. Theocharides, A. Maurer, H. M. Schueler, E. M. Buhl, K. Pannen, J. Baumeister, M. Kalmer, S. Gupta, P. Boor, , S. Koschmieder

This study shows CALR mutations in iPS cells from MPN patients accelerate megakaryocyte maturation and identify hypoxia signaling as a therapeutic target.

Stem Cell Reports · Nov 1, 2021Peer-reviewedCancer Biology

Human DC3 Antigen Presenting Dendritic Cells from Induced Pluripotent Stem Cells

T. Satoh, M. A. Szymanski de Toledo, J. Boehnke, K. Olschok, N. Flosdorf, K. Goetz, C. Kuestermann, S. Sontag, K. Sere, S. Koschmieder, T. H. Bruemmendorf, N. Chatain, Y.-i. Tagawa, M. Zenke

This paper describes the generation of human DC3 antigen-presenting cells from induced pluripotent stem cells and examines the effect of JAK2 V617F mutations on their differentiation.

bioRxiv · Jun 22, 2021Immunology

Polyelectrolyte Coating of Ferumoxytol Differentially Impacts on Labeling of Inflammatory and Steady-State Dendritic Cell Subtypes

N. Celikkin, J. E. Wong, M. Zenke, T. Hieronymus

This study shows that polyelectrolyte coating of ferumoxytol improves labeling of steady-state dendritic cells and reduces cytotoxicity compared to uncoated ferumoxytol.

bioRxiv · May 27, 2021Cell Biology

Met-signaling controls Dendritic Cell migration by regulating podosome formation and function

A. E. I. Hamouda, C. Schalla, A. Sechi, M. Zenke, T. Hieronymus

This study shows Met-signaling regulates dendritic cell migration by controlling podosome formation and ECM degradation, with both HGF-dependent and -independent effects.

bioRxiv · Apr 28, 2021 · PreprintCell Biology

Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia and chronic myelogenous leukemia

T. Wilhelm, M. A. Toledo, I. Simons, C. Stuth, V. Mohta, R. Mülfarth, M. Nitsche, K. Maschke-Neuss, S. Schmitz, A. Kaiser, M. Arock, M. Zenke, M. Huber

The paper shows that combining low-dose Ponatinib and Trametinib can overcome Imatinib resistance in mast cell leukemia by inhibiting paradoxical MAPK pathway activation.

bioRxiv · Aug 31, 2020Cancer Biology

Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic Mastocytosis

M. A. Szymanski de Toledo, M. Gatz, S. Sontag, K. V. Gleixer, G. Eisenwort, K. Feldberg, F. Kluge, R. Guareschi, G. Rossetti, A. S. Sechi, O. Dufva, S. M. Mustjoki, A. Maurer, H. M. Schueler, R. Goetzke, , M. Zenke

This study identifies nintedanib as a novel KIT D816V inhibitor effective against patient-derived neoplastic mast cells in systemic mastocytosis.

bioRxiv · May 6, 2020Cancer Biology

LSP1-myosin1e bi-molecular complex regulates focal adhesion dynamics and cell migration

K. Schaeringer, S. Maxeiner, C. Schalla, S. Ruetten, M. Zenke, A. Sechi

This study shows that the LSP1-myosin1e complex regulates focal adhesion dynamics and cell migration in macrophages by controlling actin cytoskeleton remodeling.

bioRxiv · Feb 26, 2020Cell Biology