Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality
Y.-J. Kim, B. Kang, S. Kweon, S. Oh, D. Kim, D. Gil, H. Lee, J. Kim, J. H. Ju, T.-Y. Roh, C. P. Hong, H.-J. Cha
The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.
bioRxiv · Dec 17, 2023 · PreprintCell Biology