D. Gil

A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

This paper develops a multi-antigen mRNA/LNP-based pan-CoV vaccine that provides cross-protective immunity against multiple SARS-CoV-2 variants in a hamster model.

Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality

The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

This paper describes a multi-epitope vaccine that provides cross-protection against multiple SARS-CoV-2 variants by inducing functional T cell responses.

Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis in vivo

The paper investigates metabolic adaptations in winner and loser oncogenic mutant stem cells in skin epidermis, revealing distinct metabolic strategies that drive cell competition outcomes.

Computational investigation of IP3 diffusion

The paper uses a stochastic model of Ca2+ puffs to reanalyze in vivo IP3 diffusion data, finding an effective diffusion coefficient of ~100 µm²s⁻¹, consistent with buffering by inactive IP3 receptors.

High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

Dynamin-like proteins are essential for vesicle biogenesis in Mycobacterium tuberculosis.

This study identifies dynamin-like proteins IniA and IniC as essential for extracellular vesicle biogenesis in Mycobacterium tuberculosis under iron limitation and VirR restriction.

The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans

This study identifies the structural unit of melanin in the fungal pathogen Cryptococcus neoformans, revealing its organization into nanospheres and granules.