Author

S. L. Barnes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

N. M. Belliveau· 4 shared R. Phillips· 4 shared G. Chure· 2 shared J. B. Kinney· 2 shared M. Lewis· 2 shared M. Razo-Mejia· 2 shared T. Einav· 2 shared W. T. Ireland· 2 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiophysics

N. M. Belliveau

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4 papers

Recent·Most cited

The Energetics of Molecular Adaptation in Transcriptional Regulation

G. Chure, M. Razo-Mejia, N. M. Belliveau, T. Einav, Z. A. Kaczmarek, S. L. Barnes, M. Lewis, R. Phillips

The paper links mutations in a transcriptional repressor to biophysical parameters, showing how changes in free energy predict gene expression and epistasis.

bioRxiv · May 15, 2019Biophysics

Mapping DNA sequence to transcription factor binding energy in vivo

S. L. Barnes, N. M. Belliveau, W. T. Ireland, J. B. Kinney, R. Phillips

This study develops a method to map DNA sequences to transcription factor binding energy using in vivo data, achieving predictions within 1 kBT of measured values and exploring sequence-context relationships.

bioRxiv · May 25, 2018Biophysics

A systematic approach for dissecting the molecular mechanisms of transcriptional regulation in bacteria

N. M. Belliveau, S. L. Barnes, W. T. Ireland, D. L. Jones, M. J. Sweredoski, A. Moradian, S. Hess, J. B. Kinney, R. Phillips

The paper introduces a systematic method combining assays and modeling to dissect bacterial promoter mechanisms at nucleotide resolution.

bioRxiv · Jan 6, 2018Biophysics

Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction

M. Razo-Mejia, S. L. Barnes, N. M. Belliveau, G. Chure, T. Einav, M. Lewis, R. Phillips

The paper develops a predictive theory of allosteric transcriptional regulation using the Monod-Wyman-Changeux model and validates it with experimental data on bacterial simple repression motifs.

bioRxiv · Jun 26, 2017Biophysics