D. L. Jones

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

Real-time pooled optical screening with single-cell isolation capability.

This paper introduces a method for real-time pooled optical screening with single-cell isolation using optical tweezers and 3D microfluidics.

Make Like a Tree and Leave: How Will Tree Species Loss and Climate Change Alter Future Temperate Broadleaved Forests?

The paper models how climate change and tree disease will affect temperate broadleaved forests in Wales, predicting changes in species composition and carbon dynamics over 30 years.

A diversity of diversities: do complex environmental effects underpin associations between below- and aboveground taxa?

This study examines how environmental factors and biotic interactions shape biodiversity relationships between above- and belowground taxa across multiple habitats in Wales.

The septate junction component Bark beetle is required for Drosophila intestinal barrier function and homeostasis

This study shows that Bark beetle is essential for maintaining intestinal barrier function and homeostasis in Drosophila by regulating tricellular junctions.

Genetic mapping reveals Pou2af2-dependent tuning of tuft cell differentiation and intestinal type 2 immunity

The paper identifies Pou2af2 isoform usage as a regulator of tuft cell differentiation and intestinal type 2 immunity through genetic mapping in mice.

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz

The paper shows that mechanical tension regulates tendon cell function through Yap/Taz by modulating chromatin accessibility and catabolic gene expression.

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.

Diverse soil RNA viral communities have the potential to influence grassland ecosystems across multiple trophic levels

The paper characterizes soil RNA viral communities across different soil types and finds they have broad host ranges and significant differences in community composition.

Identification and predictability of soil quality factors and indicators from conventional soil and vegetation classifications

This study assesses the relationship between soil biological indicators and soil type or vegetation cover, finding that soil type cannot reliably predict soil quality indicators but can be used with vegetation classes to characterize soil types.

Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the Epidermal Growth Factor Receptor

This study shows Neuroglian enhances EGFR signaling in Drosophila intestinal stem cells, promoting proliferation and affecting age-related changes.

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

A time-resolved imaging-based CRISPRi screening method

This paper introduces a CRISPRi screening method combining time-lapse imaging and microfluidic devices to study gene knockdown effects on E. coli cell cycle dynamics.

Two-step concentration of complex water samples for the detection of viruses

This paper validates a two-step method for concentrating enteric viruses in water samples, achieving over 10% recovery across different matrices and enabling high concentration factors.

A systematic approach for dissecting the molecular mechanisms of transcriptional regulation in bacteria

The paper introduces a systematic method combining assays and modeling to dissect bacterial promoter mechanisms at nucleotide resolution.