Cancer BiologybioRxivPreprint
eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers
J. A. Waldron, G. Kanellos, R. C. L. Smith…·O. J. Sansom
This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.
DOI 10.1101/2023.11.10.566546