Author

S. L. McLaughlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

D. J. Klinke· 4 shared W. Deng· 4 shared A. Fernandez· 3 shared A. C. Pirkey· 1 shared S. Rellick· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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4 shared papersCancer Biology

D. J. Klinke

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4 papers

Recent·Most cited

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

A. Fernandez, W. Deng, S. L. McLaughlin, A. C. Pirkey, S. Rellick, D. J. Klinke

This study shows that CCN4 promotes immunosuppression in melanoma by reducing CD8+ T cells and increasing MDSCs, and that its removal enhances immune checkpoint therapy effectiveness.

bioRxiv · Feb 23, 2021Cancer Biology

Cell Communication Network factor 4 (CCN4/WISP1) shifts melanoma cells from a fragile proliferative state to a resilient metastatic state

W. Deng, A. Fernandez, S. L. McLaughlin, D. J. Klinke

This study shows CCN4 promotes melanoma metastasis by shifting cells from a proliferative to a resilient state, with implications for therapy and biomarker development.

bioRxiv · May 25, 2019Cancer Biology

WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Stimulates Melanoma Cell Invasion and Metastasis by Promoting Epithelial - Mesenchymal Transition (EMT)

W. Deng, A. Fernandez, S. L. McLaughlin, D. J. Klinke

This study shows WISP1 promotes melanoma invasion and metastasis by inducing EMT through Akt and MAP kinase pathways.

bioRxiv · Sep 26, 2018Cancer Biology

Quantifying Spontaneous Metastasis In A Syngeneic Mouse Melanoma Model Using Real Time PCR

W. Deng, S. L. McLaughlin, D. J. Klinke

This paper develops a qPCR method to quantify spontaneous metastasis in a syngeneic mouse melanoma model, showing higher sensitivity than bioluminescence imaging.

bioRxiv · May 11, 2017Cancer Biology