Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model
D. L. N. F. Maeda, D. Tian, H. Yu, N. Dar, V. Rajasekaran, S. Meng, H. Mahsoub, H. Sooryanarain, B. Wang, C. L. Heffron, A. Hassebroek, T. LeRoith, X.-J. Meng, S. L. Zeichner
This paper develops a bacterial vaccine platform expressing coronavirus fusion peptides on genome-reduced E. coli, showing protection against disease in pigs without sterilizing immunity.
bioRxiv · Mar 15, 2021Microbiology