D. Tian

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in normal and human mitochondrial disease models

This study identifies bacterial muropeptides as activators of ATP synthase, improving mitochondrial function and reducing stress in human cells and mice.

Global terrestrial nitrogen uptake and nitrogen use efficiency

The paper quantifies global nitrogen uptake and use efficiency in plants using regression models and remote sensing data, finding that NUE is influenced by climate and allocation patterns.

Severe inbreeding and gene loss in the historical and extant population of the critically endangered Devils Hole pupfish

The paper examines genomic consequences of inbreeding and genetic loss in Devils Hole pupfish, finding extreme inbreeding and deleterious mutations affecting fitness.

Tetratricopeptide repeat domain 36 protects renal tubular cells from cisplatin-induced apoptosis via maintaining mitochondrial homeostasis

This study shows TTC36 protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial homeostasis and autophagy.

A recombinant receptor-binding domain in trimeric form generates completely protective immunity against SARS-CoV-2 infection in nonhuman primates

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model

This paper develops a bacterial vaccine platform expressing coronavirus fusion peptides on genome-reduced E. coli, showing protection against disease in pigs without sterilizing immunity.

IgY antibodies against Ebola virus possess post-exposure protection and excellent thermostability

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

Population genetics of the highly polymorphic RPP8 gene family

The paper investigates the polymorphism of the RPP8 gene family in Arabidopsis, finding that balancing selection contributes to its high diversity despite low heterozygosity.