T. LeRoith

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice

This study shows that reducing macrophage-derived Dnase1L3 in mice causes mild lupus-like symptoms, suggesting its role in preventing lupus.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

This study develops an FcRn-targeted mucosal vaccine that reduces SARS-CoV-2 infection and transmission in mice and hamsters by inducing protective immune responses in the airways.

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.

This study shows that adenovirus-mediated ACE2 expression in mice causes obesity-specific morbidity, complicating research on SARS-CoV-2 pathogenesis in different nutritional states.

Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model

This paper develops a bacterial vaccine platform expressing coronavirus fusion peptides on genome-reduced E. coli, showing protection against disease in pigs without sterilizing immunity.