mRNA delivery of dimeric human IgA protects mucosal tissues from bacterial infection
C. E. Deal, A. F. Richards, T. Yeung, M. J. Maron, Z. Wang, Y.-T. Lai, B. R. Fritz, S. Himansu, E. Narayanan, D. Liu, R. Koleva, S. Licht, C. J. Hsiao, I. L. Rajlic, H. Koch, , O. J. Plante
The paper demonstrates that mRNA-delivered human IgA can protect mucosal tissues from bacterial infection by trafficking to mucosal sites and limiting bacterial invasion.
bioRxiv · Jan 3, 2023 · PreprintImmunology