Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
E. M. Ensink, T. Jordan, H. C. Dias de Medeiros, G. Thurston, A. Pardal, L. Yu, S. Lunt
This study shows that PKM2 knockout in pancreatic cancer cells increases resistance to cystine starvation-induced ferroptosis by reprogramming glutamine metabolism through ME1 to produce NADPH.
bioRxiv · Sep 15, 2023 · PreprintCancer Biology
A. Magen, P. Hamon, N. Fiaschi, L. Troncoso, E. Humblin, D. D'souza, T. Dawson, M. D. Park, J. Kim, S. Hamel, M. Buckup, C. Chang, A. Tabachnikova, H. Schwartz, N. Malissen, , Merad
The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.
bioRxiv · Jun 22, 2022 · PreprintImmunology
V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard
This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.
bioRxiv · Apr 23, 2022 · PreprintImmunology
P. K. Kim, C. J. Halbrook, S. A. Kerk, S. Wisner, D. M. Kremer, P. Sajjakulnukit, S. W. Hou, G. Thurston, A. Anand, L. Yan, L. Salamanca-Cardona, S. D. Welling, L. Zhang, M. R. Pratt, K. R. Keshari, , C. A. Lyssiotis
This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.
bioRxiv · Sep 14, 2020 · PreprintCancer Biology
S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis
This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.
bioRxiv · Aug 7, 2020Cancer Biology
A. M. Leader, J. A. Grout, C. Chang, B. Maier, A. Tabachnikova, L. Walker, A. Lansky, J. LeBerichel, N. Malissen, M. Davila, J. Martin, G. Magri, K. Tuballes, Z. Zhoa, F. Petralia, , M. Merad
The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.
bioRxiv · Jul 16, 2020 · PreprintImmunology
C. J. Halbrook, G. Thurston, A. McCarthy, B. S. Nelson, P. Sajjakulnukit, A. S. Krall, P. J. Mullen, L. Zhang, S. Batra, A. Viale, B. Z. Stanger, H. R. Cristofk, J. Zhang, M. Pasca di Magliano, C. Jorgensen, C. A. Lyssiotis
The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.
bioRxiv · May 15, 2020 · PreprintCancer Biology
D. M. Kremer, B. S. Nelson, L. Lin, E. Yarosz, C. J. Halbrook, S. A. Kerk, P. Sajjakulnukit, A. Myers, G. Thurston, S. Hou, E. S. Carpenter, A. Andren, Z. Nwosu, N. Cusmano, S. Wisner, , C. A. Lyssiotis
This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.
bioRxiv · Feb 28, 2020 · PreprintCancer Biology