BiophysicsbioRxiv
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B
T. S. Mehlman, J. T. Biel, S. M. Azeem…·D. A. Keedy
This study compares cryo and room-temperature crystallography of PTP1B with small-molecule fragments, showing RT reveals different binding modes and conformational changes.
DOI 10.7554/elife.84632