Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism
Q. Yu, D. Ni, J. Kowal, I. Manolaridis, S. M. Jackson, H. Stahlberg, K. P. Locher
This study presents cryo-EM structures of ABCG2 under turnover conditions, revealing conformational changes that elucidate the transport mechanism and substrate specificity.
bioRxiv · Mar 3, 2021Biophysics