H. Stahlberg

The paper presents the first cryo-EM structure of a functional menaquinol:organohalide oxidoreductase from Desulfitobacterium hafniense, revealing its mechanism of electron transfer and energy conservation during organohalide respiration.

The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

The paper reports cryo-EM structures of mouse ACE2 bound to Spike proteins of four SARS-CoV-2 variants, revealing mutations that enhance binding and immune evasion.

The paper presents the cryo-EM structure of human thyroglobulin, revealing its 3D structure and providing insights into hormone synthesis and glycosylation sites.

The paper determines the cryo-EM structures of ExbBSm and ExbB-ExbDSm complex, identifies key residues for function and interaction with TonB/HasB, and reveals the role of ExbBSm extension in heme acquisition.

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

This study presents cryo-EM structures of ABCG2 under turnover conditions, revealing conformational changes that elucidate the transport mechanism and substrate specificity.

This study presents cryo-EM structures of ABCG2 bound to anticancer drugs, revealing how it recognizes and binds exogenous compounds and the structural basis for drug-induced ATPase activity.

The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

This study uses cryo-EM to show that hACE2 binding causes SARS-CoV-2 Spike trimer disassembly and S1 domain rearrangement, suggesting a mechanism for soluble hACE2's therapeutic effect.

This study uses cryo-electron tomography to reveal the architectural diversity of the centriole cartwheel region across four species, showing structural variations in periodicity and organization.

This study uses structural and functional analyses to reveal how myelin protein P2 forms a supramolecular lattice between lipid bilayers, identifying key residues and interactions involved in membrane binding.

The paper develops a method to improve resolution and resolve conformational heterogeneity in 2D crystals using single-particle refinement, achieving 4 Å resolution for the MloK1 potassium channel.

This paper introduces a microfluidic method for isolating and preparing proteins for cryo-EM, enabling high-resolution structure determination from minimal cell lysate.

The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.

This study characterizes the molecular structure and function of myelin protein P0, showing how its extracellular domains stack lipid membranes and stabilize the intraperiod line in peripheral myelin.

Focus is a software package that streamlines cryo-EM data collection and processing by integrating data import, management, and real-time monitoring in a user-friendly environment.

The paper develops image-processing algorithms to improve 3D structure determination from badly ordered 2D crystals, achieving resolution improvements to approximately 5 Å.