Author

K. P. Locher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Kowal· 3 shared D. Ni· 2 shared H. Stahlberg· 2 shared I. Manolaridis· 2 shared C.-w. Lin· 1 shared J. D. Neuhaus· 1 shared J. Eyring· 1 shared M. Aebi· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

J. Kowal

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivMay 17, 2021

Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases

J. D. Neuhaus, R. Wild, J. Eyring…·M. Aebi

This study functionally analyzes Ost3p and Ost6p subunits in yeast OST, showing their roles in catalytic activity and substrate specificity.

DOI 10.1093/glycob/cwab084

yeastexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivMar 3, 2021

Structures of ABCG2 under turnover conditions reveal a key step in drug transport mechanism

Q. Yu, D. Ni, J. Kowal…·K. P. Locher

This study presents cryo-EM structures of ABCG2 under turnover conditions, revealing conformational changes that elucidate the transport mechanism and substrate specificity.

DOI 10.1038/s41467-021-24651-2

𝕏 PostBluesky

BiophysicsbioRxivFeb 18, 2021

Structural basis of drug recognition by the multidrug transporter ABCG2

J. Kowal, D. Ni, S. Jackson…·K. P. Locher

This study presents cryo-EM structures of ABCG2 bound to anticancer drugs, revealing how it recognizes and binds exogenous compounds and the structural basis for drug-induced ATPase activity.

DOI 10.1016/j.jmb.2021.166980

𝕏 PostBluesky