Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes
H. Sulzen, A. N. Volkov, R. Geens, F. Zahedifard, B. Stijlemans, M. Zoltner, S. Magez, Y. G.-J. Sterckx, S. Zoll
This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.
PLOS Pathogens · Apr 22, 2024Peer-reviewedBiochemistry