Author

S. McDowell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. F. Haynes· 2 shared K. Janowska· 2 shared K. Manne· 2 shared K. Mansouri· 2 shared P. Acharya· 2 shared R. Henderson· 2 shared R. J. Edwards· 2 shared R. Parks· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

B. F. Haynes

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2 papers

Recent·Most cited

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity

S. Gobeil, K. Janowska, S. McDowell, K. Mansouri, R. Parks, V. Stalls, M. F. Kopp, K. Manne, K. O. Saunders, R. J. Edwards, B. F. Haynes, R. Henderson, P. Acharya

This study examines how mutations in SARS-CoV-2 spike protein affect its structure, conformation, and antigenicity across variants from different origins.

bioRxiv · Mar 11, 2021Microbiology

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction

S. Gobeil, K. Janowska, S. McDowell, K. Mansouri, R. Parks, K. Manne, V. Stalls, M. Kopp, R. Henderson, R. J. Edwards, B. F. Haynes, P. Acharya

This study shows the D614G mutation in SARS-CoV-2 spike protein increases furin cleavage efficiency and alters RBD dynamics through allosteric effects.

bioRxiv · Oct 11, 2020Biophysics