The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
T. Dinh, Z. Tber, J. S. Rey, S. Mengshetti, A. S. Annamalai, R. Haney, L. Briganti, F. Amblard, J. R. Fuchs, P. Cherepanov, K. Kim, R. F. Schinazi, J. R. Perilla, B. Kim, M. Kvaratskhelia
This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.
bioRxiv · Jan 26, 2024Microbiology