Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade
Z. Li, S. Mi, O. I. Osagie, J. Ji, C.-P. H. Yang, M. Schwartz, P. Hui, G. S. Huang
This paper identifies ARID1A-deficient cancer cells as vulnerable to pyrimidine synthesis blockade and shows synergy between teriflunomide and AZD6738 in suppressing ARID1A-mutant tumors.
bioRxiv · Oct 12, 2020 · PreprintCancer Biology