J. Ji

Human left ventricle circRNA-miRNA-mRNA network analyses reveals a novel proangiogenic role for circNPHP1 under ischemic conditions

This study identifies a circRNA-miRNA-mRNA network in ischemic heart disease, revealing circNPHP1's role in enhancing angiogenesis by sponging miR-221-3p to upregulate VEGF-A and BCL2.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Exploring the Mechanism of Gentiana in Treating Pancreatic Cancer Based on Network Pharmacology and Molecular Docking Techniques

This study identifies 72 common genes and 15 signaling pathways involved in Gentiana's potential treatment of pancreatic cancer using network pharmacology and molecular docking.

Molecular Insights into AGS3's Role in Spindle Orientation: A Biochemical Perspective

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy

This paper develops a deep learning method to automate measurement of glomerular basement membrane and podocyte foot process widths in TEM images of podocytopathy mouse models, showing comparable accuracy to manual methods.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

Contrasting Phyllosphere Mycobiome in two Lycopodiaceae Plant Species: Unraveling Potential HupA-Producing Fungi and Fungal Interactions

This study compares the mycobiome of two Lycopodiaceae species, identifying potential HupA-producing fungi and their interactions in Huperzia asiatica.

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

This study evaluates a multivalent mRNA vaccine against SARS-CoV-2 variants in mice, showing broad protection against multiple strains.

A minimal sequence motif drives selective tRNA dihydrouridylation by hDUS2

This study identifies a minimal GU motif that directs hDUS2 to modify U20 in tRNA and develops a platform to screen inhibitors of hDUS2.

A combined computational-biochemical approach offers an accelerated path to membrane protein solubilization

This paper combines computational modeling and biochemical screening to identify effective detergents for solubilizing membrane proteins, showing computational predictions better predict solubilization than experimental screening.

Lactylation-driven FTO-mediated m6A modification of CDK2 aggravates diabetic microvascular anomalies

This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-assisted Stimulated Raman Cytology

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

The brassinosteroid biosynthesis gene TaD11-2A controls grain size and its elite haplotype improves wheat grain yields

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

Significant cross-species gene flow detected in the Tamias quadrivittatus group of North American chipmunks

The paper reanalyzes genomic data from North American chipmunks to detect cross-species gene flow using a full likelihood method, finding robust evidence for ancient nuclear introgression.

Dihydroartemisinin broke immune evasion through YAP1/JAK1/STAT1, 3 pathways to enhance anti-PD-1 therapy in hepatocellular carcinoma

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

NR2F1 is a barrier to dissemination of early-evolved mammary cancer cells

The paper identifies NR2F1 as a barrier to early dissemination of HER2+ mammary cancer cells, showing its regulation by tumor suppressive and oncogenic pathways and its role in epithelial-mesenchymal transition.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade

This paper identifies ARID1A-deficient cancer cells as vulnerable to pyrimidine synthesis blockade and shows synergy between teriflunomide and AZD6738 in suppressing ARID1A-mutant tumors.

One-Step Rapid Quantification of SARS-CoV-2 Virus Particles via Low-Cost Nanoplasmonic Sensors in Generic Microplate Reader and Point-of-Care Device

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

Inhibitor of the spindle assembly checkpoint surpasses apoptosis sensitizer in synergy with taxanes

This study shows that inhibiting the spindle assembly checkpoint (SAC) is more effective than apoptosis sensitizers in enhancing taxane-induced tumor cell growth arrest.

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification

This study identifies CDX2-regulated genes and regulatory elements in mouse embryos, revealing how CDX2 represses pluripotent genes during trophectoderm and inner cell mass specification.