Structural model of microtubule dynamics inhibition by Kinesin-4 from the crystal structure of KLP-12 - tubulin complex
S. Taguchi, J. Nakano, T. Imasaki, T. Kita, Y. Saijo-Hamano, N. Sakai, H. Shigematsu, H. Okuma, T. Shimizu, E. Nitta, S. Kikkawa, S. Mizobuchi, S. Niwa, R. Nitta
The paper reports the crystal structure of KLP-12-tubulin complex, revealing how KLP-12 inhibits microtubule dynamics by altering tubulin curvature.
bioRxiv · Feb 14, 2022Biophysics