Author

H. Okuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:structural biology· 2 Organism:C. elegans· 1

Frequent Co-Authors

K. P. Campbell· 4 shared M. E. Anderson· 4 shared A. S. Walimbe· 3 shared D. Venzke· 3 shared J. M. Hord· 3 shared S. Joseph· 3 shared T. Yonekawa· 3 shared E. Nitta· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

K. P. Campbell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse

T. Yang, I. Chandel, M. Gonzales, H. Okuma, S. J. Prouty, S. Zarei, S. Joseph, K. W. Garringer, S. Ocampo Landa, T. Yonekawa, A. S. Walimbe, D. P. Venzke, M. E. Anderson, J. M. Hord, K. P. Campbell

The paper identifies a shorter matriglycan on dystroglycan that maintains neuromuscular function in adult mice and protects skeletal muscle from damage.

bioRxiv · Dec 20, 2023 · PreprintBiochemistry

Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

H. Okuma, J. M. Hord, I. Chandel, M. E. Anderson, D. Venzke, A. S. Walimbe, S. Joseph, Z. Gastel, Y. Hara, F. Saito, K. Matsumura, K. P. Campbell

This study shows that the N-terminal domain of dystroglycan is required for LARGE1 to extend matriglycan to its full length, preventing muscular dystrophy.

eLife · Feb 1, 2023Peer-reviewedBiochemistry

Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

H. Okuma, Y. Saijo-Hamano, A. A. Sherif, E. Hoshizaki, N. Sakai, T. Kato, T. Imasaki, E. Nitta, M. Sasai, Y. Maniwa, H. Kosako, D. M. Standley, M. Yamamoto, R. Nitta

The paper reveals how Toxoplasma gondii inactivates Irgb6 through ROP18-mediated phosphorylation, preventing its function in host defense.

bioRxiv · Oct 31, 2022 · PreprintMicrobiology

Structural model of microtubule dynamics inhibition by Kinesin-4 from the crystal structure of KLP-12 - tubulin complex

S. Taguchi, J. Nakano, T. Imasaki, T. Kita, Y. Saijo-Hamano, N. Sakai, H. Shigematsu, H. Okuma, T. Shimizu, E. Nitta, S. Kikkawa, S. Mizobuchi, S. Niwa, R. Nitta

The paper reports the crystal structure of KLP-12-tubulin complex, revealing how KLP-12 inhibits microtubule dynamics by altering tubulin curvature.

bioRxiv · Feb 14, 2022Biophysics

Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival

T. Yonekawa, A. J. Rauckhorst, S. Y. El-Hattab, M. A. Cuellar, D. Venzke, M. E. Anderson, H. Okuma, A. D. Pewa, E. B. Taylor, K. P. Campbell

This study shows that gene transfer using AAV2/9 CMV Large1 in older myd mice with severe muscular dystrophy restores muscle function and significantly improves survival.

bioRxiv · Oct 28, 2021Physiology

POMK Regulates Dystroglycan Function via LARGE-mediated Elongation of Matriglycan

A. S. Walimbe, H. Okuma, S. Joseph, T. Yang, T. Yonekawa, J. M. Hord, D. Venzke, M. E. Anderson, S. Torelli, A. Manzur, M. Devereaux, M. Cuellar, S. Prouty, S. Ocampo Landa, L. Yu, , K. P. Campbell

This study shows that POMK phosphorylates core M3 to enable LARGE to elongate matriglycan on dystroglycan, preventing muscular dystrophy.

bioRxiv · Apr 6, 2020Biochemistry