T. Shimizu

This study shows that maternal DHA-PL synthesis during fetal development affects offspring neuropsychiatric outcomes, but not postnatal growth or brain size.

This study develops a suspension culture method for hiPSCs using PKCβ and Wnt inhibitors to prevent spontaneous differentiation, enabling scalable and stable clinical-grade hiPSC production.

This study uses microfluidic soil chips to investigate how Rhizophagus irregularis modifies its environment through hyphal foraging and biomass allocation strategies.

This study investigates the roles of WIPI proteins in autophagy and their implications in β-propeller associated neurodegeneration, finding that WIPI2 is essential for autophagy and that some BPAN-related mutations affect autophagic activity.

This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

The paper reports the crystal structure of KLP-12-tubulin complex, revealing how KLP-12 inhibits microtubule dynamics by altering tubulin curvature.

This study determines the crystal structures of OxlT, an oxalate transporter, and reveals its mechanism for selective oxalate uptake and exclusion of other carboxylates.

This study shows that Lpcat1 deletion causes photoreceptor-specific apoptosis and increased mitochondrial ROS in mice, highlighting its role in lipid metabolism and retinal health.

The paper shows CAMSAP2 nucleates microtubules from soluble β-tubulin without γ-tubulin, reducing the nucleation barrier and forming aster-like structures.

This study uses Raman microscopy to quantify intracellular lipid physical properties, revealing that lipid droplets buffer lipid conformational ratios against compositional changes.

The paper identifies key residues and an acyl-CoA-binding pocket in mouse LPCAT2 using homology modeling, providing structural insights for drug development against PAF-related diseases.

The paper compares 12 SARS-CoV-2 molecular assays using respiratory samples, finding some have 100% specificity and high sensitivity, with recommendations for use with internal controls.

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.

This study identifies GUN1's role in chloroplast-to-nucleus retrograde signaling by showing it binds heme, affects tetrapyrrole biosynthesis, and enhances FC1 activity.

This study maintains engraftable quiescent HSCs in culture for 1 month using low cytokines, hypoxia, and high fatty acids.

This study investigates the role of LTB4-BLT1 signaling in kidney fibrosis after unilateral ureteral obstruction in mice, finding that BLT1 inhibition reduces fibrosis markers.

This study evaluates faropenem's urinary pharmacodynamics against ESBL-producing E. coli in dogs using an ex vivo model, finding that higher AUBT values correlate with lower MICs and supporting more frequent dosing.